The 2010 Astros have already drawn comparisons to the 1983 squad that lost the first nine games of the season before collecting their first victory.
That club, which finished with an 85-77 record, was led by manager Bob Lillis, who took over at the end of the previous season and went 17-17 down the stretch. Lillis went 276-261 in his four seasons.
The lowest winning percentage for an Astros manager was .308 (4-9) as Dave Clark managed the final 13 games of last season after Cecil Cooper was let go. Clark is now Houston's third-base coach.
The winningest manager in Astros history is Bill Virdon, who won 544 games games and lost 522 during his eight seasons, which is the most that anyone has managed the Astros.
The 53-year-old Mills has more than 30 years of experience in professional baseball, including 11 years as a Minor League manager and 11 seasons as a Major League coach.