"I'm feeling great," DeFrancesco said in a statement released by the team. "The treatments went well and the doctors are optimistic for a full recovery. I'm ready to go and very anxious to get back in the dugout. That's where I want to be. I'm looking forward to seeing the players and staff."
DeFrancesco was also thankful for the support he has received while undergoing treatments: "I want to thank my wife and family for all they have done for me during this time. I also can't say enough about the Astros for all the support they've given me."
"We're extremely excited for Tony," Astros player development director Quinton McCracken said. "He has shown tremendous strength while going through this, which is no surprise to us. We are looking forward to his return to Oklahoma City, and I'm sure our players, staff and the fans there are as well."
DeFrancesco, 51, has managed the RedHawks since 2011. Last season, he led Oklahoma City to an 82-62 mark, which was tops in the Pacific Coast League, despite having the youngest roster in the league. The 2014 season is his 20th as a manager.
The former catcher won three PCL championships as manager for Triple-A Sacramento (2003, '04, '07). In 2012, he served as the Astros' interim manager for the club's final 41 games, guiding Houston to a 15-15 mark over the last 30 games of the season.
Brian McTaggart is a reporter for MLB.com and writes an MLBlog, Tag's Lines. Follow @brianmctaggart on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.