The Astros observed a moment of silence in memory of the victims in Boston, Mass., and West, Texas, before Friday night's game against the Indians at Minute Maid Park.
Fans are encouraged to donate items to help the relief efforts for the residents of West affected by the explosion at the fertilizer plant.
"Whenever you have tragedy anywhere, I go to God in prayer," manager Bo Porter said. "I will continue to pray for all the people there, and I would suggest we all do the same.
"It's one of those things where things happen away from home or not really in your backyard, you mourn about it and think about it, and you have to realize there are people there who are directly affected, they're living it every day. It's not just the people who may have lost people, it's the people in the community who feel a sense of sorrow for what has happened. It's unfortunate and I pray for all parties involved."
The Astros will collect new diapers/wipes, gift cards for grocery stores or home supply stores, travel size toiletries, powdered sports drinks, toilet paper, hand sanitizer, non-perishable canned or boxed food items, clean sheets and towels (new or gently used) and unopened boxed or bagged dog and cat food.
Cash donations also will be accepted and directed to the efforts.
Cash Kruth is a reporter for MLB.com. Follow him on Twitter at @cashkruth. This story was not subject to the approval of Major League Baseball or its clubs.