Lowrie, who has started 76 games at shortstop this season, has been out of the Astros' lineup since July 15 with a nerve injury in his right leg. He completed his first rehab appearance on Friday, going 0-for-4 as the designated hitter for Double-A Corpus Christi. He was sent to Class A Advanced Lancaster on Saturday upon Corpus Christi's elimination from the playoffs.
The 28-year-old switch-hitter came on to pinch-hit in the top of the third inning on Saturday, and remained in for the rest of the 12-inning game as the DH.
Lowrie again went 0-for-4 at the plate, but drove in two runs and scored another.
"I know Jed flew to Lancaster [on Saturday] and got a couple at-bats and a couple RBIs, so that's encouraging," said Astros manager Tony DeFrancesco. "They won the game, so hopefully he'll be in the field [on Sunday] for four or five innings."
DeFrancesco said the plan was originally to have Lowrie play the field on Saturday. It would be his first field action since his injury.