"If the Astros feel that it's time for him to come up here, then it's their decision, but I have nothing against Roger -- he's a Hall of Fame pitcher," DeFrancesco said. "And we could use a guy with 300 wins."
DeFrancesco managed Clemens' oldest son, Koby, with the Astros' Triple-A affiliate in Oklahoma City last season, and said he developed a relationship with The Rocket as a result.
Clemens, who turned 50 on Aug. 4, will make his much-anticipated debut for the Sugar Land Skeeters of the independent Atlantic League on Saturday night.
"We're wishing Roger the best," DeFrancesco said. "I'm sure he's in shape and hopefully he can go out and compete, which I'm sure will determine which direction he goes in."