"Last time we were home it's like we were just stopping by," said Mills of a brief three-game homestand against the Dodgers.
Following Sunday's game in Cincinnati, Houston heads home to begin three-game series against the Mets, Cardinals and Marlins.
The homestand kicks off with a 50th Anniversary celebration when former Astros outfielder Richard Hidalgo throws out a ceremonial first pitch prior to the series opener against New York. Hidalgo will also sign autographs at Minute Maid Park before the game.
Pomp and circumstance aside, the road-weary Astros are eager to return to Houston.
"It'll be real nice to get back home, especially for a long homestand," Mills said.