Left-hander Tyler Skaggs (1-5, 4.86 ERA) will start for the Angels. He's 0-4 with a 5.61 ERA since returning from the disabled list and is seeking his first win since April 22. He's 2-2 with a 3.38 ERA in five career starts against the Astros.
Fiers (8-9, 4.78) was removed from the rotation Sept. 4 following the trade for Justin Verlander and McCullers' activation from the DL. He made his first relief appearance of the season Friday in Oakland, allowing two runs in one inning.
In his last eight starts, he was 1-5 with a 7.90 ERA. Fiers was terrific in his 10 previous starts prior to that, going 4-2 with a 2.16 ERA during a stretch where the Astros had starters Dallas Keuchel, McCullers, Charlie Morton and Collin McHugh on the disabled list at various points.
Things to know about this game
• Angels center fielder Mike Trout has reached base safely in 92 of 97 games this season. He drew his 84th walk of the season Tuesday and is trying to become the seventh player in American League history with three 100-walk seasons prior to his age-26 season.
• Astros third baseman Alex Bregman is hitting .330 with 46 runs, 20 doubles, four triples, eight homers, 32 RBIs, 22 walks and 10 steals since July 4.
• The Astros have 302 doubles this season, giving them a shot at tying the franchise record for doubles in a season -- 326 set by the 1998 team. Houston pitchers have already set a club record for strikeouts in a season with 1,411.
Brian McTaggart has covered the Astros since 2004, and for MLB.com since 2009. Follow @brianmctaggart on Twitter. This story was not subject to the approval of Major League Baseball or its clubs.