Rodriguez allowed one earned run over four innings in a rehab start for Double-A Corpus Christi on Wednesday night at Midland, Texas, and rejoined the Astros on Thursday.
"I didn't feel anything," Rodriguez said. "I'm ready."
With Rodriguez set to rejoin the rotation, who's leaving? Rookie right-handers Aneury Rodriguez, who pitches on Friday, and Jordan Lyles, who pitches on Saturday in his home debut, are the two logical options to leave the rotation, but manager Brad Mills is noncommittal.
"We'll address that later," Mills said. "I don't think that needs to be taken care of right now."
Lyles, who was called up from Triple-A Oklahoma City when Rodriguez went on the shelf, is 0-1 with a 4.91 ERA in two starts. Aneury Rodriguez is a Rule 5 pick, which means that he would have to stay on the 25-man roster or be offered back to his former team, the Rays. Aneury could be moved to the bullpen if he doesn't stay in the rotation.