Keppinger, who has been on the disabled list the entire season after undergoing foot surgery on Jan. 14, has played in 11 games during his Minor League rehab stint, splitting his time between Double-A Corpus Christi and Triple-A Oklahoma City. He was 1-for-4 on Tuesday for the RedHawks.
"I'm optimistic by the weekend he'll be back," Wade said. "We asked him to extend his stay at Oklahoma City to get back-to-back games under his belt. If everything moves in a straight line, we're looking at Friday or Saturday."
Keppinger, 31, hit .288 for the Astros last year, led the team with 34 doubles and had 59 RBIs in 137 games. He wrestled the starting second-base job away from Kaz Matsui in May and became arguably the Astros' most consistent player. Keppinger has been playing strictly second base while on his rehab assignment.