Entering Sunday, the Astros were 3-11 in Interleague Play this year, going 1-2 against Tampa Bay, 0-3 at the Yankees, 1-2 against Kansas City and 1-4 against the Rangers, who swept the Astros at Minute Maid Park last week. Houston opens a three-game series Monday at Milwaukee.
"There's no doubt it's been quite a schedule for us in Interleague," Astros manager Brad Mills said. "It's a situation where we're glad it's over with and we can get back to National League baseball."
The Astros were 10-3 against NL teams in June and 2-9 against American League teams prior to Sunday.
"You talk about momentum and it's tough to put your finger on what gets you going and what stops you," Mills said. "Playing the American League clubs in their ballpark where they have the designated hitter, that can be tough."